2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-113381A
    (R)-2-Hydroxybutanoic acid 20016-85-7 ≥98.0%
    (R)-2-Hydroxybutanoic acid is the isomer of 2-Hydroxybutyric acid (HY-113381), and can be used as an experimental control. 2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite.
    (R)-2-Hydroxybutanoic acid
  • HY-147216A
    AXKO-0046 dihydrochloride 99.68%
    AXKO-0046 dihydrochloride, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor. AXKO-0046 dihydrochloride has LDHB inhibitory activity with an EC50 value of 42 nM. AXKO-0046 dihydrochloride can be used for the research of cancer metabolism.
    AXKO-0046 dihydrochloride
  • HY-A0181BS
    Adenosine monophosphate-13C10,15N5 disodium ≥98.0%
    Adenosine monophosphate-13C10,15N5 (AMP-13C10,15N5) disodium is 13C and 15N-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
    Adenosine monophosphate-13C10,15N5 disodium
  • HY-B0228S6
    Adenosine-d2 82741-17-1 99.92%
    Adenosine-d2 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio
    Adenosine-d2
  • HY-B2219S3
    Stearic acid-d3 62163-39-7 ≥98.0%
    Stearic acid-d3 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
    Stearic acid-d3
  • HY-N0322S1
    Cholesterol-d6 60816-17-3 ≥99.0%
    Cholesterol-d6 is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.
    Cholesterol-d6
  • HY-W004874
    2,6-Dimethylhydroquinone 654-42-2 ≥98.0%
    2,6-Dimethylhydroquinone is an endogenous metabolite.
    2,6-Dimethylhydroquinone
  • HY-W007539
    2,4-Dihydroxybenzaldehyde 95-01-2 99.93%
    2,4-Dihydroxybenzaldehyde is an endogenous metabolite.
    2,4-Dihydroxybenzaldehyde
  • HY-W008642
    Leu-Leu-OH 3303-31-9
    Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs.
    Leu-Leu-OH
  • HY-W010448
    Imidazol-1-yl-acetic acid 22884-10-2 ≥98.0%
    Imidazol-1-yl-acetic acid is an endogenous metabolite.
    Imidazol-1-yl-acetic acid
  • HY-W010970
    5'-Guanylic acid disodium salt 5550-12-9 ≥98.0%
    5'-Guanylic acid disodium salt is the disodium salt form of 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid disodium salt is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid disodium salt regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid disodium salt is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid disodium salt also causes neuronal cell death at high concentrations.
    5'-Guanylic acid disodium salt
  • HY-W012480
    DL-Tryptophan 54-12-6 99.98%
    DL-Tryptophan is an endogenous metabolite.
    DL-Tryptophan
  • HY-W013706
    Inosine-5'-triphosphate trisodium salt 35908-31-7
    Inosine-5'-triphosphate trisodium salt is a nucleotide analogue that acts on multiple G proteins and is widely used in G protein-related research. It can bind to the α -subunit of G proteins and participate in G protein-mediated signal transduction as a substitute for GTP. Its mechanism of action is to interact with the nucleotide-binding site of the G protein α -subunit, affecting the activity and function of G proteins. In the research field, it is mainly used to explore the role of the G protein signaling pathway in cellular physiological and pathological processes. For example, in HL-60 leukemia cells, its impact on G protein-mediated signal transduction can be studied.
    Inosine-5'-triphosphate trisodium salt
  • HY-W014839
    Cyclamic acid sodium 139-05-9 ≥98.0%
    Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine.
    Cyclamic acid sodium
  • HY-W015560
    3,5-Dihydroxybenzoic acid 99-10-5 ≥98.0%
    3,5-Dihydroxybenzoic acid a potential biomarker for the consumption of many food products, including beer, nuts, peanut, and pulses. 3,5-Dihydroxybenzoic acid is the agonist for hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) that inhibits lipolysis in adipocytes. 3,5-Dihydroxybenzoic acid is the competitive inhibitor for tyrosine phenol-lyase (TPL), exhibits an affinity of Ki=25.7 μM. 3,5-Dihydroxybenzoic acid is orally active.
    3,5-Dihydroxybenzoic acid
  • HY-W050031
    (S)-3-Hydroxybutanoic acid 6168-83-8
    (S)-3-Hydroxybutanoic acid is a metabolite and a disease marker of depression. 3-Hydroxybutyric acid is synthesized in the liver from acetyl-CoA, and can be used as an energy source by the brain when blood glucose is low.
    (S)-3-Hydroxybutanoic acid
  • HY-N0830BS1
    Palmitic acid-13C16 sodium 2483736-17-8 ≥98.0%
    Palmitic acid-13C16 sodium is the 13C-labeled Palmitic acid sodium. Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-13C16 sodium
  • HY-10794
    MF498 915191-42-3 99.26%
    MF498 is a selective and orally active E prostanoid Receptor 4 (EP4) antagonist with a Ki value of 0.7 nM. MF498 can be used in the research of inflammation, such as rheumatoid and osteoarthritis.
    MF498
  • HY-B0881
    Acetohexamide 968-81-0 99.67%
    Acetohexamide is a first-generation sulfonylurea agent used in research related to type 2 diabetes; it stimulates the pancreas to secrete insulin.Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas.
    Acetohexamide
  • HY-B1469
    Isosorbide 652-67-5 ≥98.0%
    Isosorbide (D-Isosorbide), an orally active vasodilating agent that can be used for the research of heart failure and angina (chest pain). Isosorbide is also an oral hyperosmotic diuretic.
    Isosorbide
Cat. No. Product Name / Synonyms Application Reactivity